Category: Lupus
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SSB or Anti-La
When ANA is positive, SSB and SSA along with other antibodies are ordered to determine the underlying disease. SSB or Anti-La is a Ribonucleoprotein that is seen in the following conditions: Sjogren’s Syndrome Systemic Lupus Neonatal Lupus SSB Antibodies are rare in other connective tissue diseases and rheumatoid arthritis. SSB presence is associated with: Primary…
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SSA or Anti-Ro
When ANA is positive, SSA along with other antibodies are ordered to determine the underlying disease. SSA or Anti-Ro are antinuclear antibodies that are seen in the following conditions: Sjogren’s Syndrome Systemic Lupus Subacute Cutaneous Lupus Photosensitive Dermatitis SSA Antibodies are rare in other connective tissue diseases and rheumatoid arthritis. SSA presence is associated with:…
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Anti-Smith (anti-Sm)
Important points about Anti-Smith (anti-Sm) antibodies are: – This test along with anti-RNP are used to determine the cause of the positive ANA. – ANA is non-specific and can be seen in Lupus as well as other rheumatic diseases. Anti- Smith antibodies on the other hand are very specific for Lupus. – Anti -Smith antibodies…
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Complements
Complements are group of proteins that are involved in inflammation. The activation of the complements occur in the following settings: Systemic Lupus Glomerulonephritis Complement deficiencies Complement levels of C3, C4, and CH50 usually can indicate complement activation. CH50 indicates activity of the overall complement system. There are nine major complement proteins but C3 and C4…
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